Thermo Fisher Scientific Phospho-CSF1R (Tyr699) Polyclonal Antibody
인산화된 Tyr699 부위의 CSF1R를 특이적으로 검출하는 Rabbit Polyclonal Antibody. 인간 및 생쥐 시료에 반응하며 Western blot에 최적화. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-CSF1R (Tyr699) Polyclonal Antibody
Thermo Fisher Scientific Phospho-CSF1R (Tyr699) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CSF1R (Accession P07333), corresponding to amino acid residues around phosphorylated Tyr699 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816609 |
Product Specific Information
This antibody detects endogenous levels of MCSF Receptor only when phosphorylated at Tyr699.
Target Information
CSF1R (FMS) is a tyrosine kinase transmembrane receptor involved in macrophage production, differentiation, and function. Ligand binding activates receptor kinase through oligomerization and transphosphorylation. It belongs to the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in CSF1R are associated with myeloid malignancy predisposition. CSF1R acts as a receptor for CSF1 and IL34, regulating survival, proliferation, and differentiation of hematopoietic precursor cells, particularly macrophages and monocytes. It promotes the release of proinflammatory chemokines in response to IL34 and CSF1, playing a key role in innate immunity and inflammatory processes.
The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.