Thermo Fisher Scientific Phospho-CSF1R (Tyr708) Polyclonal Antibody
Phospho-CSF1R (Tyr708) 항체로, 인산화된 CSF1R 단백질을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 적합하며, 인간, 생쥐, 랫트 시료에 반응합니다. 고순도 정제 및 글리세롤 안정화로 장기 보관이 용이합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CSF1R (Accession P07333), corresponding to amino acid residues around phosphorylated Tyr708 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816610 |
Product Specific Information
This antibody detects endogenous levels of MCSF Receptor only when phosphorylated at Tyr708.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in the CSF1R gene are associated with predisposition to myeloid malignancy.
This receptor plays an essential role in regulating survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes such as macrophages and monocytes.
It also promotes proinflammatory chemokine release in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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