Thermo Fisher Scientific Phospho-Btk (Tyr223) Recombinant Rabbit Monoclonal Antibody (BtkY223-B4), APC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 5 µL / 1×10⁶ cells

Product Specifications

Available Formats

• Unconjugated (MA5-36923)
• FITC (MA5-36925)
• PE (MA5-36924)
• Custom conjugation available upon request

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily. Mutations in the BTK gene are associated with developmental blocks in B-cell maturation and immunodeficiency disorders.
BTK interacts with toll-like receptor (TLR) family members such as TLR4, TLR6, TLR8, and TLR9, which are essential for innate and adaptive immunity. Additionally, BTK associates with MyD88, TIRAP, and IRAK, but not TRAF-6, indicating its role in lipopolysaccharide signal transduction.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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