Thermo Fisher Scientific TBX5 Polyclonal Antibody
TBX5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등에 적합합니다. Human과 Rat에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 심장 발달 및 사지 형성과 관련된 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–243 of Human TBX5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547319 |
Product Specific Information
- Recommended positive controls: HeLa nuclear extract, rat brain
- Predicted reactivity: Mouse (100%), Rat (99%), Japanese Medaka (94%), Xenopus laevis (98%), Chicken (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The TBX5 gene belongs to a conserved family of genes sharing the T-box DNA-binding domain.
T-box genes encode transcription factors that regulate developmental processes.
TBX5 is closely linked to T-box 3 (ulnar mammary syndrome) on human chromosome 12.
The encoded protein may play a role in heart development and limb identity specification.
Mutations in TBX5 are associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs.
Several transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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