Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 인간·마우스·랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–300 of human SLC25A13 (NP_0011536821) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.82 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805039 |
Product Specific Information
Immunogen sequence:
MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFMSPNDF VTRYLNIFGE SQPNPKTVEL LSGVVDQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD KAGKGEVTFE DVKQVFGQTT IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE FTQFLLEIQL EHAKQAFVQR DNARTGRVTA IDFRDIMVTI RPHVLTPFVE ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELIRKIYSTL AGTRKDVEVT KEEFVLAAQK FGQVTPMEVD ILFQLADLYE PRGRMTLADI ERIAPLEEGT
Positive Samples: MCF7, SW480, HepG2, HeLa
Cellular Location: Mitochondrion inner membrane, Multi-pass membrane protein
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion.
It is expressed in liver, pancreas, kidney, brain, heart, and placenta, functioning as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
Citrin belongs to the mitochondrial carrier family, containing three Solcar repeats and four EF-hand domains for calcium binding.
Defects in the SLC25A13 gene cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
- CTLN2: Autosomal recessive disease linked to urea cycle errors, characterized by neuropsychiatric symptoms (memory loss, seizures, coma).
- NICCD: Non-lethal infant disorder with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-88623_SLC25A13_Q9UJS0-1_Rabbit.svg, PA5-88623_SLC25A13_Q9UJS0-1_Rabbit_PDP.jpeg)
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