Thermo Fisher Scientific Phospho-beta Catenin/gamma Catenin (Tyr489, Tyr480) Polyclonal Antibody
인간, 마우스, 랫트에서 인산화된 베타 및 감마 카테닌(Tyr489, Tyr480)을 검출하는 폴리클로날 항체입니다. Western blot 및 면역세포화학에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-beta-Catenin (Tyr-489) synthetic peptide corresponds to amino acid residues around tyrosine 489 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-480). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942894 |
Product Specific Information
This antibody was cross-adsorbed to phospho-beta-Catenin (Tyr-654) peptide before affinity purification using phospho-beta-Catenin (Tyr-489) peptide (without carrier).
It detects 84 and 88 kDa proteins corresponding to gamma-Catenin and beta-Catenin, respectively, on SDS-PAGE immunoblots of A431 cells treated with pervanadate, but does not detect these proteins in control cells.
Target Information
beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. Cadherins are transmembrane adhesion molecules found with catenins at adherens junctions.
Deletions in the cytoplasmic domain of E-Cadherin eliminate catenin binding and result in loss of cell adhesion.
Tyrosine phosphorylation of beta-Catenin regulates its interaction with adherens junction components.
Fer and Fyn kinases phosphorylate tyrosine 142 in vitro, and overexpression disrupts alpha-/beta-Catenin interactions.
Phosphorylation of tyrosine 142 may switch beta-Catenin between transcriptional and adhesive roles.
Src family kinases also phosphorylate tyrosine 86 and 654 in beta-Catenin, with Tyr-654 phosphorylation regulating E-Cadherin binding.
Site-specific tyrosine phosphorylation of beta-Catenin may thus control protein-protein interactions affecting cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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