Thermo Fisher Scientific COL11A2 Polyclonal Antibody
COL11A2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%) 제품으로 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1200–1250 of Human COL11A2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720985 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 near the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer, where the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing produces PARP, a proline/arginine-rich protein.
Mutations in this gene are associated with several disorders including:
- Type III Stickler syndrome
- Oto-spondylo-megaepiphyseal dysplasia (OSMED syndrome)
- Weissenbacher-Zweymuller syndrome
- Autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)
- Autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53)
Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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