Thermo Fisher Scientific NPAS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family are transcription factors containing a bHLH DNA binding domain located amino-terminal to a PAS domain.
Neuronal PAS domain protein 2 (NPAS2, also designated PAS4/MOP4) is a member of the bHLH-PAS family and the PAS superfamily. NPAS2, which maps to chromosome 2p11.2–2q13, is expressed primarily in neurons during the first week of postnatal development.
The expression pattern of NPAS2 temporally matches the development of learning and memory, and spatially matches the frontal association/limbic forebrain pathway. NPAS2 may play a regulatory role in the development and maintenance of long-term memory, and may be required for processing complex sensory information.
NPAS2 and MOP3 form a transcriptionally active heterodimer that binds to a CACGTGA-containing DNA element and drives transcription from a linked luciferase reporter gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.