Thermo Fisher Scientific NPAS2 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal NPAS2 항체. Western blot에 1:500~1:1,000 희석으로 사용 가능. 합성 펩타이드(aa 403-448) 면역원으로 제작. 항원 친화 크로마토그래피로 정제, PBS/glycerol buffer로 제공. 단기 4°C, 장기 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 403–448 of Human NPAS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719268 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family are transcription factors containing a bHLH DNA binding domain located amino-terminal to a PAS domain.
Neuronal PAS domain protein 2 (NPAS2, also designated PAS4/MOP4) is a member of the bHLH-PAS family and the PAS superfamily. NPAS2, which maps to chromosome 2p11.2–2q13, is expressed primarily in neurons during the first week of postnatal development.
The expression pattern of NPAS2 temporally matches the development of learning and memory, and spatially matches the frontal association/limbic forebrain pathway. NPAS2 may play a regulatory role in the development and maintenance of long-term memory, and may be required for processing complex sensory information.
NPAS2 and MOP3 form a transcriptionally active heterodimer that binds to a CACGTGA-containing DNA element and drives transcription from a linked luciferase reporter gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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