Thermo Fisher Scientific TGF alpha Polyclonal Antibody
인간, 마우스, 랫트 시료에 반응하는 TGFα 폴리클로날 항체. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, PBS/glycerol 완충액에 보관. 세포 성장 및 EGF 수용체 신호 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human TGFα |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803503 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor and stimulates proliferation of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independent transformation in cultured cells. Human, murine, and rat TGF-α are cross-species reactive. TGFα (aa 50) shares 33% homology with EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and promotes cell proliferation. It plays a role in tumor initiation by inducing a reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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