Thermo Fisher Scientific KCNJ11 Polyclonal Antibody
KCNJ11 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. 인간 시료에 반응하며, KATP 채널 연구에 유용합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 보관을 권장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human KCNJ11 (Kir6.2) conjugated to blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen shares 94% identity with rat and mouse sequence.
- Specificity: KCNJ11.
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels allow potassium to flow more readily into the cell than out. Their voltage dependence is regulated by extracellular potassium concentration; as external potassium increases, the voltage range of channel opening shifts positively.
Inward rectification results mainly from blockage of outward current by internal magnesium.
These channels can be blocked by extracellular barium.
KCNJ11 forms part of the ATP-sensitive potassium channels (KATP), and can associate with ABCC9 to form cardiac and smooth muscle-type KATP channels.
KCNJ11 forms the channel pore, while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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