Thermo Fisher Scientific Phospho-MEK1 (Ser298) Recombinant Rabbit Monoclonal Antibody (MEK1S298-H8)
Phospho-MEK1 (Ser298)을 인식하는 재조합 토끼 단일클론 항체로, Western blot과 유세포분석에 최적화됨. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현됨. PBS 기반 완충액에 보관되며, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MEK1S298-H8 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser298 of human phospho MEK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897004 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening for optimal production candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase involved in the MAPK signaling cascade, regulating cell growth and differentiation. It is activated by various growth factors, cytokines, and calcium influx through phosphorylation at Ser218 and Ser222 by Raf1.
MEK1 plays roles in stress response, apoptosis, and cytokine-induced proliferation. Mutations in MAP2K1 can cause cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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