Thermo Fisher Scientific Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6)

Thermo Fisher Scientific Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6)

Applications and Tested Dilution

• Western Blot (WB): Assay-dependent
• Immunocytochemistry (ICC/IF): 1:100
• Flow Cytometry (Flow): 1–1,000 ng/mL

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

Target Information

STAT1 (Signal Transducer and Activator of Transcription 1) is a transcription factor activated by interferons (α, β, γ), EGF, PDGF, and IL6. It regulates genes involved in cell growth, apoptosis, immune response, and lipid metabolism.
Located on chromosome 2, STAT1 activation occurs through phosphorylation by JAK kinases, followed by nuclear translocation to regulate gene transcription.
STAT1, STAT3, STAT5a, and STAT5b show wide activation profiles. STAT1 responds to multiple ligands including:

• IFN family (IFN-α, IFN-β, IFN-γ, IL-10)
• gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF)
• Receptor tyrosine kinases (EGF, PDGF, CSF-1)

Two alternatively spliced transcript variants encoding distinct STAT1 isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지