Thermo Fisher Scientific Phospho-FLT3 (Tyr842) Polyclonal Antibody
Phospho-FLT3 (Tyr842) 특이적 폴리클로날 항체로, 인간 및 랫트 반응성. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A로 정제된 액상 형태이며, -20°C 저장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr842 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FLT3 is a tyrosine protein kinase that belongs to the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation. The activated receptor subsequently phosphorylates and activates multiple cytoplasmic effector molecules involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in constitutive activation of this receptor are associated with acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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