Thermo Fisher Scientific IGF1 Recombinant Rabbit Monoclonal Antibody (ARC0505)
Recombinant Rabbit Monoclonal Antibody targeting IGF1 (ARC0505). Validated for IHC (Paraffin) and ELISA. High specificity and sensitivity for human and mouse IGF1. Supplied in liquid form with 1 mg/mL concentration, suitable for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0505 |
| Immunogen | Synthetic peptide corresponding to amino acids 70–150 of human IGF1 (P05019) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848965 |
Product Specific Information
Immunogen sequence:
GFYFNKPTGY GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKTQKYQPPS TNKNTKSQRR K
Target Information
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a significantly higher growth-promoting activity. It induces various cellular responses, including proliferation, differentiation, migration, and survival. IGF1 acts as a polypeptide growth factor stimulating proliferation in muscle, bone, and cartilage tissues and enhances glucose uptake in osteoblastic cells at lower concentrations than insulin.
In circulation, IGFs are mainly bound to IGF binding proteins (IGFBPs), which extend their half-life and assist in tissue delivery. IGF1 is one of the most potent activators of the AKT signaling pathway, promoting proliferation and inhibiting apoptosis. Mature human IGF1 is 100% homologous with bovine and porcine proteins. Low IGF1 levels have been associated with Alzheimer’s disease. Mutations in the IGF1 gene cause insulin-like growth factor 1 deficiency, and multiple transcript variants encoding different isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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