Thermo Fisher Scientific HLA-DRA Recombinant Rabbit Monoclonal Antibody (ARC0518)
Thermo Fisher Scientific의 HLA-DRA 재조합 토끼 단일클론 항체로, 인간 시료에 반응합니다. WB, IHC, ELISA 등 다양한 응용에 적합하며 HEK293 세포에서 발현되었습니다. 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0518 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human HLA-DRA (P01903) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848969 |
Product Specific Information
Immunogen sequence:
KRSNYTPITN VPPEVTVLTN SPVELREPNV LICFIDKFTP PVVNVTWLRN GKPVTTGVSE TVFLPREDHL FRKFHYLPFL PSTEDVYDCR VEHWGLDEPL L
Target Information
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
The alpha chain is approximately 33–35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-35064_HLA-DRA_P01903-1_Rabbit.svg, MA5-35064_HLA-DRA_P01903-1_Rabbit_PDP.jpeg)
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