Thermo Fisher Scientific p130cas Polyclonal Antibody
Thermo Fisher Scientific의 p130cas 폴리클로날 항체로 인간 시료에 반응합니다. Western blot에 적합하며, 세포 접합부 및 세포질에서 p130cas 단백질 검출에 사용됩니다. 고순도 항원 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
- Positive control: HeLa, T47-D, A431, C6, Raw264.7, PC12, NIH 3T3 cell lysates
- Cellular location: Cell junction, focal adhesion, Cytoplasm
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human p130cas |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins. It has a unique structure containing a Src homology (SH)-3 domain, multiple YXXP motifs, and a proline-rich region.
p130Cas is involved in biological processes such as cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection.
Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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