Thermo Fisher Scientific Collagen I Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL
• Positive Control: SW156 cells, Placenta
• Cellular Location: Extracellular Matrix

Product Specifications

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. It is a member of group I collagen (fibril-forming collagen) found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive classical Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms linked to COL1A2 mutations tend to be less severe than those in COL1A1, reflecting the different roles of alpha-2 chains in matrix integrity.
Reciprocal translocations between chromosomes 17 and 22 (where Collagen Type I genes and the PDGFB gene are located) are associated with dermatofibrosarcoma protuberans due to unregulated growth factor expression.
Two transcripts, resulting from alternate polyadenylation signals, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.