Thermo Fisher Scientific UNC5A Polyclonal Antibody

Thermo Fisher Scientific UNC5A Polyclonal Antibody

Applications and Tested Dilutions

• Western Blot (WB): 1:1,000–1:3,000
• Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total UNC5A.

Target Information

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. When cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1.
In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion. Mutation of these receptors provides a potential mechanism for tumorigenicity.
The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers.
UNC5H1 (UNC5HA, unc-5 homolog A) is a member of the UNC5H family and localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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