Thermo Fisher Scientific CD7 Monoclonal Antibody (MEM-186)
인간 CD7 단백질에 특이적인 Mouse IgG1 단클론 항체로, WB, IHC, Flow Cytometry, IP 등 다양한 응용에 적합. 비결합형 액상 형태로 제공되며, Protein A 정제 및 PBS 완충액에 보관. CD7 발현 분석 및 백혈병 진단 연구용에 유용.
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Thermo Fisher Scientific CD7 Monoclonal Antibody (MEM-186)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Flow Cytometry (Flow) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-186 |
| Immunogen | Human acute myelogenous leukaemia cell line KG-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073324 |
Available Conjugated Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly), and acute lymphocytic leukemia cells.
Western Blot: non-reducing conditions recommended.
Target Information
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, while the C-terminal region is proline-rich and forms a stalk projecting the Ig domain.
CD7 is expressed on most immature and mature T-lymphocytes, T cell leukemia, NK cells, a small subset of normal B cells, and malignant B cells. Cross-linking CD7 enhances T cell and NK cell activity, influencing calcium flux, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces D-3 phosphoinositide production and tyrosine phosphorylation. CD7 expression serves as a key marker in leukemia diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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