Thermo Fisher Scientific CD6 Monoclonal Antibody (MEM-98)
CD6 단백질을 인식하는 MEM-98 클론의 마우스 단일클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, Flow cytometry, IP 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 형태이며, 4°C 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Flow Cytometry (Flow) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-98 |
| Immunogen | Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125–128) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073200 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD6, a 100–130 kDa single-chain transmembrane glycoprotein expressed on T and B lymphocyte subsets, thymocytes, and acute lymphocytic leukemia cells.
Western blot is recommended under non-reducing conditions.
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a co-receptor for T cell activation and stabilizer of the immunological synapse.
CD6–ALCAM mediated cell adhesion is important for T cell proliferation. CD6 may exert some functions via association with CD5, potentially fine-tuning CD5 signaling.
Ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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