Thermo Fisher Scientific PICK1 Polyclonal Antibody
Rabbit polyclonal antibody against human PICK1, validated for WB, IHC, and ICC/IF. Recognizes Human, Mouse, and Rat. Affinity-purified with >95% purity. Supplied in PBS with sodium azide, ideal for synaptic protein localization studies.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PICK1 (amino acids 1–415, UniProt ID: Q9NRD5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719811 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by epitope-specific immunogen affinity chromatography. The purity is >95% as determined by SDS-PAGE.
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization.
PICK1 (Protein Interacting with Protein Kinase C) is a synaptic PDZ domain protein that also contains coiled-coil and acidic domains.
PICK1 functions as a targeting and transport protein, interacting with PKCα, AMPA-type glutamate receptors, and other membrane receptors via its PDZ domain.
The interaction with PKCα depends on kinase activation and directs activated PKCα to membrane-anchored GluR2. Once phosphorylated, GluR2 is released and transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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