Thermo Fisher Scientific TOP3B Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human TOP3B if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOP3B,uniProtId:O95985-1,ncbiNodeId:9606,antigenRange:421-505,antigenLength:862,antigenImageFileName:PA5-67061_TOP3B_O95985-1_Rabbit.svg,antigenImageFileNamePDP:PA5-67061_TOP3B_O95985-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662322

Product Specific Information

Immunogen sequence: SHDCKYLQSTI SFRIGPELFT CSGKTVLSPG FTEVMPWQSV PLEESLPTCQ RGDAFPVGEV KMLEKQTNPP DYLTEAELIT LMEK

Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

Target Information

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I and DNA topoisomerase II relax both positive and negative supercoils, DNA topoisomerase III relaxes only negative supercoils. DNA topoisomerase III alpha exists as a long and a short isoform, which are produced by alternative splicing. DNA topoisomerase III alpha, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. DNA topoisomerase III beta exists as three isoforms, namely beta1, beta2 and beta3, also produced by alternative splicing. DNA topoisomerase III beta1 is expressed in testes, heart and skeletal muscle, whereas beta2 is expressed in thymus, kidney and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.