Thermo Fisher Scientific ATP2C1 Polyclonal Antibody
ATP2C1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, ICC/IF에 적합. 인간 ATP2C1 재조합 단백질을 면역원으로 사용하며, 토끼 IgG 형식의 비결합 액상 제품. Hailey-Hailey 질환 및 세포 내 Ca2+/Mn2+ 운반 연구에 활용 가능.
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Thermo Fisher Scientific ATP2C1 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATP2C1 (amino acids 356–427) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663112 |
Product Specific Information
- Immunogen sequence:
TKNEMTVTHIF TSDGLHAEVT GVGYNQFGEV IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT E - Highest antigen sequence identity: mouse 99%, rat 99%
Target Information
ATP2C1, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in ATP2C1 cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and skin erosions.
Unlike the related ATP2C2 protein, ATP2C1 is ubiquitously expressed and shows a lower maximal turnover rate for Ca²⁺-ATPase reaction but a higher affinity for cytosolic Ca²⁺.
Recent studies suggest ATP2C1 regulates IGF1R processing in tumor progression of basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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