Thermo Fisher Scientific IRAK2 Polyclonal Antibody
Human IRAK2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA519937
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the carboxy terminus of human IRAK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154300 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 65 kDa.
- Suggested positive control: K562 cell lysate.
- PA5-19937 can be used with blocking peptide PEP-0062.
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, a pivotal transcription factor mediating inflammatory and immune response.
A novel member in the IRAK/Pelle family, designated IRAK2, recruits to subunits of the IL-1R complex after IL-1 binding and leads to NF-kappa-B activation.
IRAKs also associate with Toll-like receptor (TLR), and dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation.
Members in the IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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