Thermo Fisher Scientific Phospho-FGFR1 (Tyr654) Polyclonal Antibody
FGFR1의 Tyr654 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr654 (D-Y-YP-K-K) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554873 |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 growth factors (FGF1–17) and play crucial roles in biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms expressed differently during embryonic development and in adults. Mutations or defects in FGFR1 are associated with several diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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