Thermo Fisher Scientific Phospho-FGFR1 (Tyr654) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 growth factors (FGF1–17) and play crucial roles in biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.

FGFR1 undergoes alternative splicing, producing multiple isoforms expressed differently during embryonic development and in adults. Mutations or defects in FGFR1 are associated with several diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.