Thermo Fisher Scientific ETS1 Polyclonal Antibody
Rabbit polyclonal antibody against human ETS1 protein. Validated for WB, IHC (Paraffin), and ICC/IF applications. Supplied as liquid form at 1 mg/mL. For research use only, not for diagnostic or resale purposes.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human ETS1 around the phosphorylation site of Thr38 (L-L-TP-P-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554871 |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein belonging to the DNA-binding ETS family. It contains an N-terminal pointed domain, a central transactivation domain, and two auto-inhibitory domains flanking the conserved C-terminal ETS domain.
ETS1 interacts with transcription factors such as PEBP2alphaA and p300/CBP, mediating transactivation of genes including Osteopontin, Presenilin-1, Stromelysin, and Collagenase. It is activated by Ras/MAPK signaling and upregulated in resting T-cells. Activity is modulated by AP-1, Sp-1, c-myb, and MafB. ETS1 is activated by Sp100 in nuclear bodies, interacts with EAP1/Daxx to repress MMP1 and BCL2 transactivation, and associates with STAT6 to regulate Socs-1 expression induced by IL-4. It also interacts with GATA3 to positively regulate Tax-1–dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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