Thermo Fisher Scientific BRAF (V600E Mutant Specific) (Prognostic Marker) Monoclonal Antibody (V600E/1322)
BRAF(V600E) 변이 특이적 단일클론 항체로, 인간 시료에 반응하며 예후 마커 연구용으로 적합. ELISA 등 다양한 분석에 사용 가능. 단백질 A로 정제된 액상 항체로, 4°C에서 보관. 연구용으로만 사용.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | V600E/1322 |
| Immunogen | An eleven amino acid residue long synthetic peptide (aa596-606), corresponding to Cys-GLAT(E)KSRWSG from human BRAF protein. It was conjugated to KLH at the N-terminus. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The B-RAF/BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein regulates the MAP kinase/ERK signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in this gene, particularly the V600E mutation, are among the most common cancer-causing mutations in melanoma and have also been identified in other cancers such as non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia, and lung adenocarcinoma.
Additionally, mutations are associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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