Thermo Fisher Scientific BRAF (V600E Mutant Specific) (Prognostic Marker) Monoclonal Antibody (V600E/1322)
BRAF(V600E) 변이 특이 단일클론 항체로, 인간 시료에서 예후 마커 연구용으로 사용됩니다. ELISA 등 다양한 응용에 적합하며, 단백질 A로 정제된 액상형 항체입니다. 냉동(-20°C) 보관하며 방부제는 포함되어 있지 않습니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | V600E/1322 |
| Immunogen | An eleven amino acid residue long synthetic peptide (aa596–606), corresponding to Cys-GLAT(E)KSRWSG from human BRAF protein. It was conjugated to KLH at the N-terminus. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The B-RAF/BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein regulates the MAP kinase/ERK signaling pathway, influencing cell division, differentiation, and secretion.
Mutations, particularly V600E, are the most common cancer-causing mutations in melanoma and are also found in other cancers such as non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia, and lung adenocarcinoma.
Additionally, mutations are associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene exists on the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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