Thermo Fisher Scientific EIF4E2 Monoclonal Antibody (OTI4E7), TrueMAB
Human EIF4E2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P)에서 검증됨. 동결건조 형태로 제공되며 재구성 시 1 mg/mL 농도 유지. 번역 개시 억제 관련 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E7 |
| Immunogen | Full length human recombinant protein of human EIF4E2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
EIF4E2 recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in translation initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349).
Acts as a repressor of translation initiation (PubMed:22751931).
Unlike EIF4E, it does not bind eIF4G (EIF4G1, EIF4G2, EIF4G3), suggesting competitive inhibition of eIF4F assembly at the cap. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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