Thermo Fisher Scientific SP110 Monoclonal Antibody (OTI2A1), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Susceptibility to tuberculosis (TB) in mice has been linked to the IPR1 gene, a member of the SP100/SP140 family of nuclear body proteins.
SP110 encodes a leukocyte-specific nuclear body component that functions as a transcription activator and potential nuclear hormone receptor coactivator.
Alternative splicing produces three distinct isoforms. SP110 is the closest human homolog of the murine IPR1 protein and may integrate signals from intracellular pathogens with innate immunity, cell death, and pathogenesis mechanisms.
IPR1/SP110 expression is upregulated upon Mycobacterium tuberculosis infection and is necessary for Anaplasma phagocytophilum infection in human promyelocytic cells.
Defects in SP110 are associated with impaired resistance to M. tuberculosis infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.