Thermo Fisher Scientific OCRL Polyclonal Antibody
Human OCRL 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human OCRL. Recombinant protein control fragment (Product # RP-92194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644948 |
Product Specific Information
Immunogen sequence:
DYFLTISGNY LPSCFGTSLE ALCRMKRPIR EVPVTKLIDL EEDSFLEKEK SLLQMVPLDE GASERPLQVP KEIWLLVDHL FKYACHQEDL FQTPGMQEEL QQIIDCLDTS IPETIPGSNH SVAEALLIFL EALPEPVICY ELY
Sequence identity (orthologs):
- Mouse: 97%
- Rat: 99%
Target Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, generating second messengers in response to extracellular signals.
OCRL1 is a type II 5-phosphatase mutated in the oculocerebrorenal syndrome of Lowe (OCRL), a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction.
OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate, and inositol 1,3,4,5-tetrakisphosphate as substrates. It localizes to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting a role in protein sorting and intracellular trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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