Thermo Fisher Scientific OCRL Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human OCRL. Recombinant protein control fragment (Product #RP-92194). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OCRL,uniProtId:Q01968-1,ncbiNodeId:9606,antigenRange:666-808,antigenLength:901,antigenImageFileName:PA5-52938_OCRL_Q01968-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52938_OCRL_Q01968-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644948

Product Specific Information

Immunogen sequence: DYFLTISGNY LPSCFGTSLE ALCRMKRPIR EVPVTKLIDL EEDSFLEKEK SLLQMVPLDE GASERPLQVP KEIWLLVDHL FKYACHQEDL FQTPGMQEEL QQIIDCLDTS IPETIPGSNH SVAEALLIFL EALPEPVICY ELY

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 99%.

Target Information

The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder that is characterized in part by congenital cataracts, mental retardation, muscular hypotonia and renal tubular dysfunction. OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates. OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), which suggests that OCRL1 plays a role in protein sorting and trafficking within the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.