Thermo Fisher Scientific GPLD1 Polyclonal Antibody
인간 GPLD1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체입니다. IHC(P)에서 1:20~1:50 희석으로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GPLD1. Recombinant protein control fragment (Product #RP-102400). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642146 |
Product Specific Information
Immunogen sequence:
FWSTNIYHLT SFMLENGTSD CNLPENPLFI ACGGQQNHTQ GSKMQKNDFH RNLTTSLTES VDRNINYTER GVFFSVNSWT PDSMSFIYKA LERNIRTMFI GGSQLSQKHV SS
- Highest antigen sequence identity to the following orthologs:
- Mouse: 65%
- Rat: 68%
Target Information
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum, where it associates with apolipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides.
Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein. Cleavage of the GPI moiety by GPLD1, the only enzyme known to cleave the GPI anchor, may regulate the attachment of these proteins to the cell surface or their release into the extracellular environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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