Thermo Fisher Scientific GPLD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GPLD1. Recombinant protein control fragment (Product #RP-102400). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GPLD1,uniProtId:P80108-1,ncbiNodeId:9606,antigenRange:256-367,antigenLength:840,antigenImageFileName:PA5-52941_GPLD1_P80108-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52941_GPLD1_P80108-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642146

Product Specific Information

Immunogen sequence: FWSTNIYHLT SFMLENGTSD CNLPENPLFI ACGGQQNHTQ GSKMQKNDFH RNLTTSLTES VDRNINYTER GVFFSVNSWT PDSMSFIYKA LERNIRTMFI GGSQLSQKHV SS

Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.

Target Information

GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.