Thermo Fisher Scientific CD4 Monoclonal Antibody (RPA-T4), Alexa Fluor 488, eBioscience
인간 CD4 항원에 특이적인 RPA-T4 단클론 항체로, Alexa Fluor 488 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며 HIV 결합 차단 기능을 가집니다. 고순도 친화 크로마토그래피 정제, 4°C 암소 보관.
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Thermo Fisher Scientific CD4 Monoclonal Antibody (RPA-T4), Alexa Fluor 488, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 18 publications |
| Neutralization (Neu) | - | View 2 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RPA-T4 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2762473 |
Available Formats
- Unconjugated
- Alexa Fluor 532
- Alexa Fluor 561
- Alexa Fluor 647
- Alexa Fluor 660
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 496 / 615 / 661 / 737 / 805
- Brilliant Violet 421 / 480 / 605 / 650 / 711
- eFluor 450 / 506
- FITC
- Functional Grade
- NovaFluor Blue 510 / 585 / 690
- Pacific Orange
- PE / PE-Cyanine5 / PE-Cyanine5.5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5 / PerCP-eFluor 710
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation
Product Specific Information
Description:
The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by most thymocytes, a subpopulation of mature T cells (T-helper cells), and at low levels on monocytes. CD4 serves as a receptor for HIV, and RPA-T4 blocks HIV binding and mixed lymphocyte reaction. RPA-T4 recognizes a different epitope from OKT4 and does not cross-block.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-diluted and validated for flow cytometric analysis of normal human peripheral blood cells. Use 5 µL (0.25 µg) per test (final volume 100 µL). Suitable for 10⁵–10⁸ cells/test.
Excitation/Emission: 488 nm / 519 nm
Laser: Blue Laser
Target Information
CD4 antigen is involved in MHC class II recognition and acts as a co-receptor for HIV. Expressed mainly on T-helper lymphocytes, but also found on monocytes, macrophages, and dendritic cells. Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain brain and gut regions. CD4 aids early T-cell activation via interaction with the TCR complex and Lck kinase, and may mediate neuronal damage in infectious or immune CNS diseases. Multiple alternatively spliced transcripts identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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