Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), PE-Cyanine7, eBioscience
인간 CD8a를 인식하는 SK1 단클론 항체로, PE-Cyanine7 형광체가 결합된 제품입니다. 흐름 세포분석(Flow Cytometry)에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. CD8 양성 T세포 및 NK세포 분석에 적합하며, 광민감성 주의 및 4°C 암소 보관이 필요합니다.
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Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), PE-Cyanine7, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry
- Tested Dilution: 5 µL (0.06 µg)/test
- Publications: View 15 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK1 |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10734503 |
Available Formats
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 650
- eFluor 450
- FITC
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation available
Product Specific Information
The SK1 monoclonal antibody reacts with the human CD8a molecule, a 32–34 kDa cell surface receptor expressed as CD8 alpha/beta heterodimer or CD8 alpha/alpha homodimer. CD8a is expressed on most thymocytes, subsets of mature T cells, and NK cells. It binds MHC class I and associates with tyrosine kinase p56lck for T-cell development and activation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated for flow cytometry on normal human peripheral blood cells (5 µL/test)
- Light Sensitivity: Protect from light; tandem dye is photo-sensitive
- Fixation: Samples can be stored in IC Fixation Buffer (Product #00-822-49) or 1-step Fix/Lyse Solution (Product #00-5333-54) for up to 3 days at 4°C in the dark
- Excitation: 488–561 nm
- Emission: 775 nm
- Laser Compatibility: Blue, Green, Yellow-Green lasers
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD8 is a type I transmembrane glycoprotein that functions as a co-receptor with TCR for MHC class I molecules. It is expressed on T cells, NK cells, monocytes, and dendritic cells, typically as CD8α/β heterodimers or CD8α/α homodimers. Engagement with MHC-I/peptide complexes triggers Lck recruitment, leading to CTL activation and pathogen/tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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