Thermo Fisher Scientific TPA Recombinant Rabbit Monoclonal Antibody (JF0958)
Recombinant rabbit monoclonal antibody (clone JF0958) targeting human tPA. Validated for WB and IHC(P). Offers high specificity, lot-to-lot consistency, and animal-free formulation. Supplied as liquid, 1 mg/mL, Protein A purified, stored at 4°C or -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF0958 |
| Immunogen | Synthetic peptide within Human Tissue-type plasminogen activator (aa 523–562) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809784 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
Tissue-type plasminogen activator (TPA) converts plasminogen to plasmin by hydrolyzing a single Arg-Val bond. It plays a crucial role in tissue remodeling, cell migration, and various physiological and pathological events.
TPA binds fibrin with high affinity, increasing catalytic efficiency up to 1000-fold. It also interacts with heparin, laminin, fibronectin, mannose receptor, and LRP1, which are involved in clearance. Additionally, TPA binds annexin II and cytokeratin 8, and its binding to endothelial and vascular smooth muscle cells enhances plasminogen activation and reduces inhibition by PAI-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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