Thermo Fisher Scientific MERTK Recombinant Rabbit Monoclonal Antibody (SR29-07)
MERTK 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, Flow Cytometry에 적합합니다. 높은 특이성과 일관된 로트 간 품질을 제공합니다. Protein A로 정제되었으며, 4°C 또는 -20°C에서 보관 가능합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 | - |
| Flow Cytometry (Flow) | 1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SR29-07 |
| Immunogen | Recombinant protein within Human MERTK (aa 1–118) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809285 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening for optimal clones.
Key advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, associated with retinal diseases.
It regulates cell survival, migration, differentiation, and efferocytosis. Ligand binding induces autophosphorylation, creating docking sites for downstream signaling molecules such as GRB2 and PLCG2, leading to activation of MAPK1, MAPK2, FAK/PTK2, and RAC1.
MERTK signaling contributes to macrophage-mediated clearance of apoptotic cells, platelet aggregation, cytoskeletal reorganization, and inhibition of TLR-mediated innate immune responses via STAT1 activation and SOCS1/SOCS3 induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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