Thermo Fisher Scientific CDK5 Recombinant Rabbit Monoclonal Antibody (SR39-01)
CDK5 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, Flow Cytometry에 적합합니다. 높은 특이성과 일관된 생산성을 제공하며, 신경세포 발달 연구에 유용합니다. 단백질 A 정제, 1 mg/mL 농도, TBS buffer 기반 보존.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SR39-01 |
| Immunogen | Synthetic peptide within Human CDK5 (aa 243–292) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809281 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening for optimal clones.
Key advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
CDK5 (Cyclin-Dependent Kinase 5) is a kinase most abundant in the mammalian brain. The active form is a heterodimer of CDK5 and a 25 kDa protein derived from a 35 kDa neuron-specific protein, essential for kinase activity.
CDK5 regulates neuronal migration in the developing central nervous system and phosphorylates multiple substrates, influencing processes such as:
- Cell adhesion and motility
- Synaptic plasticity
- Drug addiction mechanisms
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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