Thermo Fisher Scientific NR0B2 Monoclonal Antibody (OTI8E5), TrueMAB
NR0B2 단백질을 인식하는 Mouse Monoclonal Antibody. Western Blot에 최적화되어 있으며 1:2,000 희석 권장. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 보존. -20°C에서 보관, 연구용 한정.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8E5 |
| Immunogen | Full length human recombinant protein of human NR0B2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain.
It belongs to the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones.
Some members of this family, including NR0B2, are referred to as orphan nuclear receptors as they lack known ligands.
This protein interacts with retinoid and thyroid hormone receptors to inhibit ligand-dependent transcriptional activation, and also interacts with estrogen receptors, leading to inhibition of their function.
Studies suggest that NR0B2 represses nuclear hormone receptor-mediated transactivation via two mechanisms: competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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