Thermo Fisher Scientific SAS-6 Polyclonal Antibody
SAS-6 단백질을 타겟으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunoprecipitation에 적합. 비결합형 액상 형태로 4°C에서 보관. 연구용으로만 사용 가능.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 607 and 657 of Human spindle assembly 6 (SAS-6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation rather than serving as a structural component.
Metadherin is overexpressed in breast cancer tissue and xenografts, with significantly lower levels in normal breast tissue. It binds to lung vasculature — a common site of breast cancer metastasis — via a C-terminal segment in its extracellular domain. Blocking this domain with antibodies or inhibiting metadherin using siRNA has been reported to suppress breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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