Thermo Fisher Scientific TAK1 Polyclonal Antibody
TAK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 Immunoprecipitation에 적합하며, Human 반응성을 가집니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific TAK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 450 and 500 of Human transforming growth factor-beta-activated kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-beta-activated kinase, TAK1 interacts with TGF-beta receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, responding to thyroid hormone, osmotic stress, endothelin, and ephrine. TAK1 regulates wound healing through activation of von Hippel-Lindau tumor suppressor expression and represses PDGF-B and integrins. It plays a key role in IKK activation across pathways such as IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation requires TAB2/3 and ubiquitination, leading to TAK1 autophosphorylation and subsequent IKK-beta phosphorylation. TAK1 also represses human telomerase reverse transcriptase, implicating it in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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