Thermo Fisher Scientific HPK1 Polyclonal Antibody
HPK1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 최적화. 비결합형 액상 형태로 제공되며, 4°C에서 보관. 혈액세포 분화 연구 및 MAPK 신호전달 경로 분석에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human hematopoietic progenitor kinase 1 (HPK1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
MAP4K1 (HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
It acts as an upstream activator of the MEKK/JNK/SAPK signaling pathway and regulates T cell receptor (TCR) signaling and proliferation via phosphorylation of SLP-76.
HPK1 plays a crucial role in stress response and blood cell differentiation. It specifically activates JNK1 and enhances AP-1 transcriptional activity.
Unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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