Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (MEM-189)
인간 CD71(Transferrin Receptor)에 특이적인 MEM-189 단클론 항체로, WB, ICC/IF, Flow Cytometry, IP에 사용 가능. 비환원 조건에서 Western blot 권장. Protein A로 정제된 액상 형태이며, 4°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-189 |
| Immunogen | KG1 human acute myelogenous leukaemia cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 8 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_1073355 |
Product Specific Information
This antibody reacts with an extracellular epitope on CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages, and erythroid precursors. It is lost on resting blood leukocytes.
The antibody MEM-189 does not block binding of transferrin to the receptor.
Western blot should be performed under non-reducing conditions.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is recycled to the cell surface, returning to neutral pH and losing affinity for apotransferrin.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse by athletes and as a diagnostic marker for anemias associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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