Thermo Fisher Scientific DAXX Monoclonal Antibody (DAXX-01)
DAXX 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 Immunocytochemistry에 사용 가능. Human 시료에 반응하며 Protein A로 정제된 액상 형태. 4°C 보관, PBS buffer와 sodium azide 함유. 연구용으로만 사용.
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Applications
- Western Blot (WB): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DAXX-01 |
| Immunogen | Recombinant C-terminal part (aa 558–740) of human Daxx |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073998 |
Product Specific Information
This antibody recognizes Daxx, a cytoplasmic death domain-containing protein mainly expressed in fetal and adult human and mouse tissue.
Target Information
The DAXX gene encodes a multifunctional protein localized in both the nucleus and cytoplasm. It interacts with various proteins such as Fas, centromere protein C, and transcription factor E26 homolog 1. In the nucleus, DAXX functions as a transcriptional repressor binding to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. DAXX also associates with centromeres during G2 phase and may regulate apoptosis in the cytoplasm. Its localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination. Multiple transcript variants exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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