Thermo Fisher Scientific Phospho-Beclin 1 (Ser93,Ser96) Polyclonal Antibody
Beclin 1 단백질의 Ser93/Ser96 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 자가포식 관련 연구에 활용 가능. 액상 형태로 -20°C 보관, 1 mg/mL 농도.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BECN1 (Accession Q14457), corresponding to amino acid residues around phosphorylated Ser96 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815869 |
Product Specific Information
Antibody detects endogenous levels of Beclin 1 only when phosphorylated at Ser93/96.
Target Information
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways:
- PI3KC3-C1 is involved in the initiation of autophagosomes.
- PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis.
Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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