Thermo Fisher Scientific INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (INSM1/6286R)
INSM1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 신경내분비 종양 마커 연구에 적합. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, CHO 세포에서 발현된 IgG 형식의 항체. 보존제 없이 PBS 완충액에 제공되며, -20°C에서 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSM1/6286R |
| Immunogen | Recombinant fragment (around aa81–125) corresponding to the N-terminus of human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. In mice, IA-1 expression begins as early as E9.5 in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb. It functions as a transcriptional repressor and participates in several signaling pathways, including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its potential as a therapeutic target in cancer research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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