Thermo Fisher Scientific INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (INSM1/6286R)
INSM1 단백질을 인식하는 재조합 토끼 단클론 항체로, 신경내분비 종양 마커 연구에 적합. 포르말린 고정 파라핀 절편(IHC-P) 및 PFA 고정 조직에서 사용 가능. 고순도 Protein A/G 정제, 4°C 보관. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSM1/6286R |
| Immunogen | Recombinant fragment (around aa81–125) corresponding to the N-terminus of human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IA-1 (also known as INSM1) is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. IA-1 expression begins as early as E9.5 in mice, in regions such as the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb. It functions as a transcriptional repressor and participates in signaling pathways including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors and nearly all small cell lung carcinomas, suggesting its potential as a target in cancer research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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