Thermo Fisher Scientific INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (INSM1/8122R)
INSM1을 표적하는 재조합 토끼 단클론 항체로 신경내분비 종양 연구에 적합합니다. 인간 시료 반응성을 가지며 IHC(P) 및 IHC(PFA) 실험에 사용됩니다. HEK293 세포에서 발현된 항체로 높은 순도와 안정성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSM1/8122R |
| Immunogen | Recombinant fragment (around aa1–300) of human INSM1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor initially identified from an insulinoma cDNA library. It is expressed in the developing nervous system, including the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb in mice as early as E9.5. IA-1 functions as a transcriptional repressor and participates in signaling pathways such as Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. It is also expressed in various tumors, including most neuroendocrine tumors and nearly all small cell lung carcinomas, indicating its potential as a therapeutic target in cancer research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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