Thermo Fisher Scientific Emerin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Emerin for WB, IHC, ICC/IF, and ELISA applications. High specificity and affinity-purified with 4.74 mg/mL concentration. Suitable for nuclear membrane protein detection in HeLa, Jurkat, and other cell lines.
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Thermo Fisher Scientific Emerin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–220 of human Emerin (EMD, NP_0001081) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.74 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804660 |
Product Specific Information
Immunogen sequence:
MDNYADLSDT ELTTLLRRYN IPHGPVVGST RRLYEKKIFE YETQRRRLSP PSSSAASSYS FSDLNSTRGD ADMYDLPKKE DALLYQSKGY NDDYYEESYF TTRTYGEPES AGPSRAVRQS VTSFPDADAF HHQVHDDDLL SSSEEECKDR ERPMYGRDSA YQSITHYRPV SASRSSLDLS YYPTSSSTSF MSSSSSSSSW LTRRAIRPEN RAPGAGLGQD
Positive Samples: HeLa, Jurkat, PC-3, U-251MG, Y79
Cellular Location: Nucleoplasmic side, Nucleus inner membrane, Nucleus outer membrane, Single-pass membrane protein
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of UV-induced damages. Human XPG nuclease performs the 3′ incision during nucleotide excision repair, cleaving DNA bubble structures near duplex junctions. A 29-amino acid region (residues 981–1009) contains PCNA binding activity, with Arg992 being crucial for this interaction. Replication Protein A (RPA) binds directly to two excision repair proteins, XPA and XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-88113_Emerin_P50402-1_Rabbit.svg, PA5-88113_Emerin_P50402-1_Rabbit_PDP.jpeg)
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