Thermo Fisher Scientific BAG4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human BAG4 (SODD) protein. Validated for Western blot applications. Provides reliable detection of apoptosis-related BAG family proteins. Supplied in liquid form, 0.5 mg/mL concentration. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues S(2) A L R R S G Y G P S D G P S(16) of human SODD/BAG4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2258904 |
Product Specific Information
- Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that interacts with various cell apoptosis and growth-related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors, and members of the heat shock protein 70 kDa family.
This protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. It is associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), thereby negatively regulating downstream cell death signaling.
The regulatory role of this protein in cell death has been demonstrated in epithelial cells undergoing apoptosis when integrin-mediated matrix contacts are lost.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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