Thermo Fisher Scientific SWAP70 Polyclonal Antibody
SWAP70 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 인간 시료 반응성. Protein G로 정제된 액상 형태로 안정적인 신호 검출 가능. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 1–3 µg/mL
- Suggested Positive Control: Daudi cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 300–350 of human SWAP-70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2197048 |
Target Information
SWAP70 is a 585-amino-acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding. It acts as a link between recognition of specific switch regions and DNA break formation, participating in nuclear events and B-cell activation signaling. As a guanine nucleotide exchange factor (GEF), SWAP70 transduces signals from tyrosine kinase receptors to RAC, independent of RAS. It plays roles in membrane ruffling, actin cytoskeleton regulation, and cell protrusion. SWAP70 is widely expressed in most tissues, mature B-cells, monocytes, and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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